个人简介

高静，女，医学博士、博士后，二级主任医师, 研究员，天津市胸科医院心血管病研究所副所长，生物样本库主任，天津大学和天津医科大学博士生导师，博士后合作导师，天津市“131”创新型人才培养工程第一层次人选，天津市“131”创新型人才团队带头人，天津市首届卫生计生行业高层次人才“津门医学英才”人选，天津市卫生健康系统“最美科技工作者”。

长期从事心血管疾病临床和研究工作，近年来作为带头人带领团队致力于急性心肌梗死防治临床研究、基础研究和精准医学研究，开展多组学技术在糖脂代谢和肠道菌群方向研究，在肠道菌群与急性心肌梗死发生发展及预后风险、生物标志物与心血管疾病诊疗风险预警、年轻心肌梗死诊疗预后风险评估和早期预警等方面取得系列创新成果。主持了天津市首个最大心血管疾病生物样本库建设和发展。主持建立单中心全国前列急性心肌梗死队列，建立国内先进水平的急性心肌梗死诊治医学研究创新平台和全国首个省市级全域急性心肌梗死大数据平台。创新和优化了急性心肌梗死诊疗和预警体系，部分成果达到国际领先。主持和参与国家级、省部级重点研发、重大专项等各级科研课题27项。获市级科技成果20余项，国家专利7项。获天津市科技进步二等奖2项（第一和第三完成人），获中国医院协会医院科技创新二等奖1项。代表性成果在心血管领域世界顶级国际会议ACC、ESC 、AHA、TCT和国内顶级会议中华医学会和中国医师协会全国心血管年会（CSC、CCCP）上口头报告发言和主持40 余次，极大提升天津地区心血管国际国内学术影响力。发表SCI在内学术论文110余篇，培养博、硕士研究生70余人。

现任美国心脏病学会专家委员（FACC）、欧洲心脏病学会专家委员（FESC）、美国心脏病学协会（AHA）专业会员、欧洲心脏病学年会会议评审委员会专家。国家科技计划专家库专家、国家卫生健康委医学高层次人才评审专家、国家教育部人才计划高层次人才评审专家、国家教育部学位与研究生教育发展中心评审专家、中国博士后科学基金评审专家、国家人力资源社会保障部专家服务基层重点联系专家、上海市、天津市、黑龙江省及四川省等科技局科技专家库评审专家、中国医师协会心血管内科分会第六届委员会动脉粥样硬化学组委员、中国研究型医院学会临床数据与样本资源库专业委会京津冀生物样本资源协作组副组长、 “京津冀生物样本库联盟”天津地区副主任委员，中国医药生物技术协会生物样本库分会全国委员、天津市医师协会心血管内科医师分会基础研究专委会副主任委员，天津市心脏学会理事等。《Theranostics》、《Nutrients》、《Heart and Vessels》、《BMJ Open》、《中华心血管病杂志》、《天津医药》等20余种期刊编委或审稿专家。

研究方向

1) 急性心肌梗死临床、基础与精准医学研究

2) 急性心肌梗死大数据平台应用与人工智能

3) 肠道微生态与急性心肌梗死临床与基础

4) 人工智能与年轻急性心肌梗死诊疗风险评估预测和早期预警

5) 心血管代谢与急性心肌梗死

代表性学术成果（近5年论文）

1. Yan Liang†, Lili Zhao†, Xu Zhang, Shan Liu, Pengju Lu, Jingxian Wang, Liqun Chen, Yin Liu*, Jing Gao* . Lactobacillus ameliorates myocardial ischemia reperfusion injury by attenuating apoptosis, inflammation, oxidative stress, and ferroptosis. BMC Medcine ,2025  23:377  

2. Jing-xian Wang†, Chang-ping Li †, Zhuang Cui, Yan Liang, Yu-hang Wang, Yu Zhou, An-ran Jing, Miao-miao Liang, Yin Liu*,Jing Gao*,. Machine Learning Algorithms to Predict Heart Failure with Preserved Ejection Fraction among Patients with Premature Myocardial Infarction. Frontiers in Cardiovascular Medicine. 2025.1571185

3. Jing-xian Wang†, Miao-miao Liang†, Peng-ju Lu, Zhuang Cui, Yan Liang,

Yu-hang Wang, An-ran Jing, Jing Wang, Meng-long Zhang, Yin Liu, Chang-ping Li,*Jing Gao*. Predicting MACE risk in patients with premature myocardial infarction based on machine learning. Reviews in Cardiovascular Medicine. Rev. Cardiovasc. Med. 2025; 26(5): 31298  

4. Yu-Qing Li, Ping Li, Ran Chu, Wei-Wei Tian, Jia-Xin Wang, Yin Liu, Jing Gao*. Association between the oxidative balance score and mortality in patients with metabolic syndrome. Scientific Reports, 2025,15(1):9258.

5. Yu-Hang Wang,†, Chang-Ping Li,†, Jing-Xian Wang, Zhuang Cui, Yu Zhou,An-Ran Jing, Miao-Miao Liang, Yin Liu,* , Jing Gao*.Advanced machine learning to predict coronary artery disease severity in patients with premature myocardial infarction . Reviews in Cardiovascular Medicine, 2025; 26(1): 26102.

6. Li Sun, Jing-xian Wang, Jing Ma, Xu Zhang, Yu-Hang Wang, An-Ran Jing, Miao-Miao Liang, Jing-yu Liu, Yin Liu* and Jing Gao*. Association of the PCSK6 rs1531817(C/A) polymorphism with the prognosis and coronary stenosis in premature myocardial infarction patients: a prospective cohort study. Lipids in Health and Disease, 2024 23:220

7. Kui Huang ，XiaoQin Wen，Wei Zhang，JingXian Wang，Yan Liang，WenQing Li，YuHang Wang，MiaoMiao Liang，AnRan Jing，Jing Ma，Xu Zhang，Yin Liu*,Jing Gao*. Predictive Value of 5-Methoxytryptophan on Long-Term Clinical Outcome after PCI in Patients with Acute Myocardial Infarction-a Prospective Cohort Study. J Cardiovasc Transl Res. 2024 Apr 29.

8. Ting Li†, Jing Dou†, Hong Zhang, Xuexiao Su, Yin Liu, Mingdong Gao,Jianyong Xiao, Wengui Xu*,Jing Gao*. Optimized gated a SPECT‑derived myocardial salvage index: its prognostic significance in predicting major adverse cardiac events following acute myocardial infarction percussion. Annals of Nuclear Medicine,2023, 12149-023-01894-1

9. Ting-Ting Liu#, Jie Wang#, Yan Liang, Xiao-Yuan Wu, Wen-Qing Li, Yu-Hang Wang, An-Ran Jing, Miao-Miao Liang, Li Sun, Jing Dou, Jing-Yu Liu, Yin Liu, Zhuang Cui, Jing Gao*. The level of serum total bile acid is related to atherosclerotic lesions, prognosis and gut Lactobacillus in acute coronary syndrome patients. Annals of medicine, 2023, 55(1):2232369.

10. Yan Liang , Jingxian Wang, Xiao-Yuan Wu, Yan Cui, Zhong-He Zou, Wen-Qing Li, Yin Liu*, Jing Gao*. The Prediction value of Platelet-Derived Growth Factor for Major Adverse Cardiovascular Events in Patients with Acute Non-ST-Segment Elevation Myocardial Infarction. Annals of Medicine,2023

11. Jing Gao†;Yuan Wang,MD†;Ya-Nan Yang;Xiao-Yuan Wu;Yan Cui;Zhong-He Zou ; Zhuang Cui*,Yin Liu*.  Impact of metabolic syndrome and its components on clinical severity and long-term prognosis in patients with premature myocardial infarction. Frontiers in Endocrinology 13:920470.  

12. Xiao-Wei Li1†, Yin Liu†, Ming-Dong Gao, Jian-Yong Xiao, Jing Gao* . The long-term outcome of 316 patients with STEMI following coronary stent implantation. American Journal of Translational Research,2022, 14（6）:4139-4145

13. Li-Hong Zhao†, Yin Liu †,Jian-Yong Xiao, Ji-Xiang Wang, Xiao-Wei Li, Zhuang Cui，Jing Gao* .Prognostic value of metabolic syndrome in patients with non-ST elevated myocardial infarction undergoing percutaneous coronary intervention. Frontiers in Cardiovascular Medicine . 2022,9:912999.

14. YIN Liu, JING Ma, NAN Zhang, JIAN-YON Xiao, JI-XIANG Wang , XIAO-WEI Li , JING Wang , YAN Zhang , MING-DON Gao, XU Zhang , YUAN Wang, JING-X Wang , SHI-BO Xu , JING Gao *.Latent class cluster analysis of knowledge on acute myocardial infarction symptoms and risk factors in community residents. BMJ Open 2022;12:e051952.  

15. Jing Gao§, Peng-Ju Lu§, Chang-Ping Li, Hui Wang, Ji-Xiang Wang, Nan Zhang, Xiao-Wei Li, Hai-Wang Zhao, Jing Dou, Miao-Na Bai, Yu-Tian Shi, Jia Zhao, Chun Zan, Yin Liu‡.  Reconsidering treatment guidelines for acute myocardial infarction during the COVID-19 pandemic. BMC Cardiovascular Disorders  2022,22;194

16. Xiao-Wei Li, Zhuang Cui, Jian-Yong Xiao, Ming-Dong Gao, Mei Zhang, Wen-Juan Zhang, Feng-Shi Tian,Yu Song, Ying-Wu Liu, Zhu-Hua Yao, Jun Ma, Yin Liu and Jing Gao*.  A five-parameter score for predicting saphenous vein graft degenerative and/or occlusive disease in recurring ischemic symptoms after one year post coronary artery bypass grafting. Perfusion,2022  IF1.581

17. Nan Zhang†, Jingxian Wang†, Yan Cui, Xiao-Yuan Wu, Zhong-He Zou, Yin Liu*,Jing Gao*. Correlation analysis of plasma MPO level with GRACE score and prognosis in patients with acute non-ST-segment elevation myocardial infarction. Frontiers in Medicine . 2022 9:828174.

18. Jing-Jing Cai‡,Yin Liu‡, Jie Wang, Jing-Xian, Wang,Yuan Wang,Shi-Bo,Xu, Zhuang Cui, Jing Gao*. Lactobacillus levels and prognosis of patients with acute myocardial infarction . Journal of Geriatric Cardiology. 2022,19(2);101-114.

19. Jing Gao, Jing-Yu Liu, Peng-Ju Lu, Jian-Yong Xiao, Ming-Dong Gao ,Chang-Ping Li, Zhuang Cui, and Yin Liu .Effects of Evolocumab Added to Moderate-Intensity Statin Therapy in Chinese Patients with Acute Coronary Syndrome: The EMSIACS trial study protocol. Frontiers in Physiology-Clinical and Translational Physiology . 2021; 12: 750872.

20. Jing Gao†, Jie Wang†, Li-Li Zhao, Ting-Ting Yao, Yang Chen, Jing Ma, Xu Zhang, Jing-Xian Wang, Yuan Wang, Zhuang Cui‡ ,Yin Liu‡. Gut Lactobacilluslevel is a predictive marker for coronary atherosclerotic lesions progress and prognosis in patients with acute coronary syndrome. Front. Cell. Infect. Microbiol. 2021，Sep 7;11:687827.  

21. Jixiang Wang, Honggang Gao,Jianyong Xiao, Mingdong Gao, Yin Liu*,Jing Gao*. The clinical features and prognosis of type 4C myocardial infarction in patients with non-ST-segment elevation myocardial infarction. Annals of Translational Medicine, 2021  

22. Jixiang Wang §，Peng Han§, Mingdong Gao, Jianyong Xiao, Xiaowei Li, Nan Zhang, Jing Ma, Zhuang Cui, Tingting Yao, Yang Chen, Jing Gao *, Yin Liu*.  PrognosticValue of PCSK9 Levels in Non-ST elevation myocardial infarction Patients Undergoing Percutaneous Coronary Intervention (PCI). Hellenic Journal of Cardiology, 2021  

23. Xiaowen Gong§ ,Tiantian Zhang , Siyuan Feng, Desheng Song, Yang Chen, Tingting Yao, Peng Han, Yuanyuan Liu, Changping Li, Zhen Song, Jing Gao*, Zhuang Cui *, Jun Ma, Yin Liu. Association between N-terminal pro-BNP and 12 months major adverse cardiac events among patients admitted with NSTEMI. Annals of Palliative Medicine, 2021;10(5):5231-5243. IF 2.595

24. Jing Gao§ , Ya-Nan Yang§, Zhuang Cui, Si-Yuan Feng, Jing Ma, Chang-Ping Li *and Yin Liu* . Pcsk9is associated with severity of coronary artery lesions in male patients with premature myocardial infarction. 2021，Lipids in Health and Disease.

25. Peng-Ju Lu; Xiao-Wen Gong; Yin Liu; Feng-Shi Tian,; Wen-Juan Zhang; Ying-Wu Liu; Zhu-Hua Yao; Ji-Xiang Wang; Zhuang Cui;Jing Gao*..Optimization of GRACE Risk Stratification by N-terminal Pro B-Type Natriuretic Peptide Combined with D-Dimer in Patients with Non-ST-Elevation Myocardial Infarction. The American Journal of Cardiology,2020.

26. Yi-Xing Yang; Yin Liu; Chang-Ping Li ; Peng-Ju Lu,; Jiao Wang; Jing Gao*. Clinical Outcomes of Drug-Eluting versus Bare-Metal In-Stent Restenosis after the Treatment of Drug-Eluting Stent or Drug-Eluting Balloon: A Systematic Review and Meta-Analysis. Journal of international cardiology, 2020 Jun 26;2020:8179849.  IF：2.279

27. Yi-Xing Yang,Yin Liu,Xiao-Wei Li, Peng-Ju Lu,Jiao Wang ,Chang-Ping Li , Jing Gao*.Clinical outcomes after percutaneous coronary intervention for early versus late and very late stent thrombosis: A systematic review and meta-analysis. Journal of Thrombosis and Thrombolysis.2020, Jul 20. IF：2.3

28. Jing Gao, Kun-Tao Yan, Ji-Xiang Wang, Jing Dou, Jie Wang, Min Ren, Jing Ma, Xu Zhang, Yin Liu.Gut microbial taxa as potential predictive biomarkers for acute coronary syndrome and post-STEMI cardiovascular event. Scientific Reports,2020,10:2639 . IF：4.525

29. Yin Liu,Chang-Ping Li,,Yue-Ying Wang ,Ya-Nan Dong, Hong-Wei Liu,Jian-Yong Xiao, Ming-Dong Gao, Ji-Xiang Wang, Xiao-Wei Li, Nan Zhang, Jun Ma, and Jing Gao *. Prediction of Major Adverse Cardiovascular Events and Slow/No-Reflow by Virtual Histology Imaging After Percutaneous Interventions on Saphenous Vein Grafts. Angiology, 2020,71(3)：263-273. IF：3.619

30. 晚期和极晚期支架内血栓所致STEMI患者经皮冠状动脉介入治疗后的长期临床结局. 李晓卫、杨宜兴、高明东、李长平、武小园、刘寅、高静*. 中华危重病急救医学，2024,12（36）:1290-1295.

31. 蔡景景，刘寅，高静*. 脂质组学在心血管疾病中的应用进展. 中华心血管病杂志，2022，50（6）：615-618.

32. 李晓卫,刘寅,高静*,高明东,肖健勇,屈志萍,王玥莹,冯利娟.冠状动脉旁路移植术后晚期静脉移植血管疾病的介入治疗策略比较. 中华心血管病杂志，2020,48(5):367-372.

33. 李晓卫、刘寅、高静、高明东、肖建勇、屈志萍. 冠状动脉支架置入1年后发生急性心肌梗死患者近期及远期临床结局分析. 中华医学杂志，2020，100（15）：1136-1140.

34.  Effect of PCSK9 Inhibitors on the Quality of Life in Patients with Acute Coronary Syndromes. ESC Congress 2025 Madrid. Oral Presentation

35. Prognostic Impact of the Combined Effect of Lipoprotein(a) and Homocysteine in Patients with Premature Myocardial Infarction: a Prospective Cohort Study. ESC Congress 2025 Madrid. Moderated Presentation

36. Association of free fatty acids with long-term adverse outcomes in patients with premature myocardial infarction: a prospective cohort study. ESC Congress 2025 Madrid. Moderated Presentation

37. Association between the oxidative balance score and mortality in patients with metabolic syndrome. ESC Congress 2025 Madrid. Moderated Presentation

38. Analysis of risk factors and construction of risk prediction model for type 4b acute myocardial infarction caused by very late stent thrombosis based on machine learning .ESC Congress 2025 Madrid. Moderated Presentation

39. Effect of circadian rhythm gene Period2 rs934945 gene polymorphism on long-term prognosis of patients with early onset acute myocardial infarction after PPCI: a prospective cohort study. ESC Congress 2025 Madrid. Moderated Poster Presentation

40. .Association of PCSK6 rs1531817(C/A) polymorphism with the prognosis and coronary stenosis in premature myocardial infarction patients: a prospective cohort study . ESC Congress 2024 London. Oral Presentation

41. To evaluate coronary microvascular obstruction by myocardial contrast echocardiography and its influence on prognosis in patients with ST-segment elevation myocardial infarction . ESC Congress 2024 London. Moderated Presentation

42. Analysis of risk factors in high-risk plaque in acute coronary syndrome based on LASSO regression . ESC Congress 2024 London. Moderated Poster Presentation

43. Developing Integrated Algorithms for Risk Assessment of In-Hospital Heart Failure with Preserved Ejection Fraction among Patients with Premature Myocardial Infarction. ACC Congress 2024 Atlanta

44. Advanced Machine Learning for Predicting Coronary Artery Disease Severity in Patients with Premature Myocardial Infarction. ACC Congress 2024 Atlanta.

科研项目（近5年）

已完成项目：

1) 2020年天津市重点研发计划科技支撑重点项目《天津市急性心肌梗死防控诊疗研究及大数据平台应用》经费150万元  2020.04-2023.03 第一项目负责人20YFZCSY00820

2) 2020年多中心临床研究《依洛尤单抗联合他汀治疗对急性冠脉综合征患者LDL-C变异度及主要心血管事件的影响》EMSIACS Trail  NCT 04100434

3) 2017年天津市津南区科委科技计划项目《急性心肌梗死救治临床研究和基础研究》 经费10万元  2017.12-2018.12 第一项目负责人 20171514

4) 2017年天津市科委科技计划项目《急性心肌梗死防治专项科普教育活动》经费6万元  2017.10-2018.9 第一项目负责人 17KPHDSF00200

5) 2016年天津市卫生行业重点攻关项目 《急性心肌梗死患者肠道微生态改变及益生菌干预临床研究》 第一项目负责人 16KG131  2016.12-2019.11

6) 2016年国家科技部 “十三五”重点研发计划重大慢性疾病防控研究重点专项项目“急性心肌梗死全程心肌保护体系研究”（2016YFC1301200） 子课题 2016.09-2020.12

7) 2016年天津市科技重大专项与工程项目 《急性心肌梗死院内救治早期心肌保护策略优化及评价研究》  16ZXMJSY00150  第四项目负责人 2016.10-2019.09

8) 2016年天津市科技支撑计划重点项目 《静脉移植血管疾病风险预测及VH-IVUS技术在其介入治疗中应用》 项目批准号：16YFZCSY00800    第三项目负责人 2016.04-2019.03

9) 2015年天津市卫生行业重点攻关项目《冠状动脉搭桥术后静脉移植血管疾病的防治研究》 项目批准号： 15KG128    第三项目负责人 2015.10-2018.10

在研项目：

1) 2022年天津市科技计划项目天津市自然科学基金重点项目 《乳酸杆菌改善急性心肌梗死缺血再灌注损伤的作用及机制研究》20万元 2022.10-2026.09 第一项目负责人 22JCZDJC00130

2) 2022年天津市卫生健康科技项目重点学科专项《急性心肌梗死早期PCSK9抑制剂联合他汀治疗的精准诊疗研究》20万元 2022.07-2026.06 第一项目负责人 TJWJ2022XK032

3) 2017年度天津市“131”创新型人才团队带头人: 天津市胸科医院急性心肌梗死救治临床研究和基础研究创新团队  经费120万元 2017.12 -至今

4) 2018年天津市首届卫生计生行业高层次人才“津门医学”英才 经费120万元  2017.12-至今

获奖情况

1. 《急性心肌梗死临床诊疗创新优化平台和体系的建立及应用》 2021JB-2-119  2021年获天津市科学技术进步二等奖 第一完成人

2. 《基于胸痛中心模式的动脉粥样硬化心血管诊疗技术的研究》

2021年中国医院协会医院科技创新奖 二等奖  证书号：2021-CHA-02-03-08

3. 《冠脉搭桥术后静脉移植血管疾病精准诊疗体系的建立与应用》  第三完成人 天津市科学技术进步二等奖  证书号：2019JB-2-058

4. 2022年天津市卫生健康系统“最美科技工作者”

5. 2022年作为中华人民共和国科技部中国优秀科技成果全国推广

社会学术兼职

美国心脏病学院专家委员（FACC）、欧洲心脏病学会专家委员（FESC）、美国心脏病学协会（AHA）专业会员、欧洲心脏病学年会会议评审委员会专家。

国家卫生健康委国家科技重大专项评审专家、医学高层次人才评审专家

国家教育部人才计划高层次人才评审专家、国家教育部学位与研究生教育发展中心评审专家

国家人力资源社会保障部专家服务基层重点联系专家

中国博士后科学基金评审专家

上海市、天津市、黑龙江省及四川省等科技局科技专家库评审专家

中国医师协会心血管内科分会第六届委员会动脉粥样硬化学组委员

中国研究型医院学会临床数据与样本资源库专业委会京津冀生物样本资源协作组副组长

京津冀生物样本库联盟”天津地区副主任委员

中国医药生物技术协会生物样本库分会全国委员

天津市医师协会心血管内科医师分会基础研究专委会副主任委员

天津市心脏学会理事

中华心血管病杂志、天津医药杂志等及20余种SCI期刊编委或审稿专家