张小臣-天津大学医学院

Z

张小臣

职称：副研究员、正高级工程师

办公室：天津大学10号教学楼214室

邮箱：xiaochenzhang@tju.edu.cn

个人简介

张小臣，博士，副研究员。博士毕业于南开大学，后于北京大学从事博士后阶段工作，2022年入职天津大学医学工程与转化医学研究院。长期致力于神经生物学方向的研究，通过动物行为学、电生理记录、原代细胞培养、遗传学调控等多种手段理解学习记忆及突触可塑性的机制，探究神经精神类疾病(如抑郁症、精神分裂症、焦虑症、孤独症、缺血性卒中)发病及损伤机制，同时关注神经调控技术的作用机制探究以及解析特异脑电信号的生物学基础。主持并参与国家重点研发计划、国家应用类项目、国家自然科学基金、中国博士后基金等多项国家、省部级科研项目。在包括Advance Science, PLoS Biology, Neuron, PNAS等高水平期刊上共发表SCI论文30余篇，申请及授权国家发明专利近10项。

主要研究方向

神经生物学：生理条件下学习记忆及突触可塑性的机制，病理条件下神经精神类疾病（如抑郁症、精神分裂症、焦虑症、孤独症、缺血性卒中）发病及损伤机制，关注神经调控技术的应用与调控机制，解析特异脑电信号的生物学基础。

代表性学术成果

1. Chenxiao Li¹, Xiaochen Zhang¹, Jiangwei Xia¹, Shuang Liu¹, et al., Brd4 BD1 Domain Antagonism of MS436 Preserves Blood-Brain Barrier Integrity via Rnf43/β-Catenin Signaling Pathway, Advanced Science, 2025 Nov 20:e15584. doi: 10.1002/advs.202515584.

2. Junzhao Li, Rubing Zhou, Jinpeng Wang, Xiaochen Zhang, et al., Dynamic redistribution of AMPA receptors toward memory-related neuronal ensembles in mice barrel cortex during sensory learning, Neuron, 2025 Sep 17;113(18):2979-2996.e8. doi: 10.1016/j.neuron.2025.06.002. Epub 2025 Jul 9.

3. Wei Liu, Xin Guan, Ludan Zhang, Chaoyang Zhu, Hongzuo Chu, Xiaochen Zhang#, Shuang Liu. Electroencephalographic microstate evidence of visual network hyperactivation in children with autism spectrum disorder, Journal of Intelligent Medicine, 2025 May 2(1):64-73.

4. Wanting Guo¹, Yuchen He¹, Xizi Song1, Deyu Heng, Xiaochen Zhang#, Yufeng Ke, Shuang Liu#, Dong Ming. 40-Hz Temporally Interfering Electrical Stimulation Over the Temporal Lobe Induced Antidepressant-Like Effects in Chronic Unpredictable Mild Stress Rats, IEEE Trans Neural Syst Rehabil Eng, 2025:33:1796-1804.

5. Xiaojuan Wang¹, Xiaochen Zhang¹, Yuan Chang , Jingmeng Liao , Shuang Liu , Dong Ming , Double-blind, randomized, placebo-controlled pilot clinical trial with gamma-band transcranial alternating current stimulation for the treatment of schizophrenia refractory auditory hallucinations, Transl Psychiatry, 2025 Jan 30;15(1):36.

6. Kongjie Lu, Chenyang Li, Jiao Liu, Jinpeng Wang, Yongfeng Li, Bin He, Junzhao Li, Xiaochen Zhang, et al., Impairments in endogenous AMPA receptor dynamics correlates with learning deficits in Alzheimer's disease model mice, Proc Natl Acad Sci U S A, 2023 Oct 3;120(40):e2303878120.

7. Jing Chen¹, Zhang Xiaochen¹, Liping Li¹, Xianqiang Ma, et al., Farnesyl pyrophosphate is a new danger signal inducing acute cell death, Plos Biology, 2021 Apr 26;19(4):e3001134.

8. Chunxiao Yang¹, Xiaochen Zhang¹, Hongqiang Yin, Zhanqiang Du, et al. MiR-429/200a/200b negatively regulate Notch1 signaling pathway to suppress CoCl₂-induced apoptosis in PC12 cells, Toxicology in Vitro, 2020 Jun;65:104787.

9. Xiaochen Zhang, Chunxiao Yang, Jing Gao, Hongqiang Yin, et al., Voluntary running-enhanced synaptic plasticity, learning and memory are mediated by Notch1 signal pathway in C57BL mice, Brain Structure and Function, 2018 Mar;223(2):749-767.

10. Qun Li¹, Xiaochen Zhang¹, Ning Cheng, Chunxiao Yang, et al., Notch1 knockdown disturbed neural oscillations in the hippocampus of C57BL mice, Progress in Neuro-psychopharmacology & Biological Psychiatry, 2018 Jun 8;84(Pt A):63-70.

11. Xiaochen Zhang, Hongqiang Yin, Zhigui Li, Tao Zhang, et al., Nano-TiO₂ induces autophagy to protect against cell death through antioxidative mechanism in podocytes, Cell Biology and Toxicology, 2016 Dec;32(6):513-527.

12. Xiaochen Zhang, Wen Li and Zhuo Yang, Toxicology of nanosized titanium dioxide: an update, Archives of Toxicology, 2015 Dec;89(12):2207-17.

13. Xiaochen Zhang, Zhuo Yang. Using the Whole Cell Patch Clamp Technique to Study the Effect of Nanoparticles in Hippocampal Neurons. Neuromethods, Use of Nanoparticles in Neuroscience pp 187–202.（著作）

14. Qun Li¹, Chunxiao Yang¹, Xiaochen Zhang, Zhuo Yang, et al., Arginine vasopressin attenuates dysfunction of hippocampal theta and gamma oscillations in chronic cerebral hypoperfusion via V1a receptor. Brain Research Bulletin, 2019 Nov;153:84-92.

15. Hongqiang Yin, Xiaochen Zhang, Kai Li, Zhigui Li, et al., Effects of miR-200b-3p inhibition on the TRPC6 and BKCa channels of podocytes. Archives of Biochemistry and Biophysics, 2018 Sep 1;653:80-89.

16. Chunxiao Yang, Xiaochen Zhang, Jing Gao, Mengzhen Wang, et al., Arginine vasopressin ameliorates spatial learning impairments in chronic cerebral hypoperfusion via V1a receptor and autophagy signaling partially, Translational Psychiatry, 2017 Jul 18;7(7):e1174.

17. Zhaowei Liu¹, Jiajia Yang¹, Xiaochen Zhang, Pengjuan Xu, et al., Developmetal changes in the expression and function of TRPC6 channels related the F-actin organization during differenatiation in podocytes, Cell Calcium, 2015 Dec;58(6):541-8.

18. Jing Gao, Xiaochen Zhang, Mei Yu, Guogang Ren, et al., Cognitive deficits induced by multi-walled carbon nanotubes via the autophagic pathway, Toxicology, 2015 Nov 4;337:21-9.

19. Miaomiao Wei, Chunhua Liu, Xiaochen Zhang, Xiaoniao Chen, et al., Autophagy is involved in regulating VEGF during high-glucose-induced podocyte injury. Molecular BioSystems, 2016 Jun 21;12(7):2202-12.

20. Na Gao, Hui Wang, Xiaochen Zhang, Zhuo Yang. The inhibitory effect of angiotensin II on BKCa channels in podocytes via oxidative stress. Molecular and Cellular Biochemistry, 2015 Jan;398(1-2):217-22.

21. Hui Ma, Chenyang Li, Jinpeng Wang, Xiaochen Zhang, et al., Amygdala-hippocampal innervation modulates stress-induced depressive-like behaviors through AMPA receptors. Proceedings of the National Academy of Sciences of the United States of America, 2021 Feb 9;118(6):e2019409118.

22. Kai Li, Xin Wang, Yu Jiang, Xiaochen Zhang, et al., Early intervention attenuates synaptic plasticity impairment and neuroinflammation in 5xFAD mice. Journal of Psychiatric Research, 2021 Apr;136:204-216.

23. Sitong Wang, Kai Li, Shaokai Zhao, Xiaochen Zhang, et al., Early-stage dysfunction of hippocampal theta and gamma oscillations and its modulation of neural network in a transgenic 5xFAD mouse model. Neurobiology of Aging, 2020 Oct;94:121-129.

Pengjuan Xu, Zhigui Li, Hui Wang, Xiaochen Zhang, et al., Triptolide Inhibited Cytotoxicity of Differentiated PC12 Cells Induced by Amyloid-Beta₂₅₋₃₅ via the Autophagy Pathway. PLoS One, 2015 Nov 10;10(11):e0142719.

科研项目

2026.01-2027.12，国家应用项目，负责人。

2025.01- 2027.12, 面向动态记忆处理的超精细解码与增强技术, 国家重点研发计划，课题骨干。

2023.12- 2026.11, 基于微弱物理场激励的细胞快速响应通讯元件精准构建技术，国家重点研发计划，课题骨干。

2023.03- 2024.12，面向脑认知的抑郁情绪识别模型开发，横向项目，负责人。

2019.11 - 2022.07 AMPA受体调控紊乱在阿尔兹海默病发病中作用研究，博士后面上基金，负责人。

2018.10 – 2022.07 Farnesyl pyrophosphate is a new danger signal that induces acute cell death through TRPM2，北大清华生命联合中心基金，负责人

2020.01 – 2023.12 利用单色荧光探针对突触可塑性过程中多种信号通路的可视化研究，国家自然科学基金面上项目，主要参与人

2018.01 – 2021.12 纳米材料通过细胞自噬途径影响神经突触传递及动物认知行为表征的机制研究，国家自然科学基金面上项目，主要参与人

2015.01 – 2018.12 纳米材料对神经系统发育和神经认知的影响及其机制研究，国家自然科学基金面上项目，主要参与人

2015.01 – 2017.12 Notch1受体调控GSK-3beta抑制糖尿病心肌病的机制研究，国家自然科学基金青年项目，主要参与人

获奖情况