个人简介

孙思，博士，天津大学助理研究员。毕业于天津大学理学院，师从张晓东教授。长期聚焦于团簇分子的理性设计及其在重大疾病中的应用。近年来，在Nature Communications，Advanced Materials，ACS Nano，Nano Letters, Nano Today等TOP期刊发表论文30余篇，授权国家发明专利1项。参与国家重点研发计划、国自然面上、天津市面上项目等。入选2025年国家资助博士后研究人员计划C档资助，获天津大学2025年度天津大学优秀博士学位论文。

代表性学术成果

[1] Si Sun, Fangzhen Tian, Huanhuan Qiao, Qi Xin, Xinxu Zhang, Nan Song, Yuxing Yan, Ling Liu, Yili Wang, Lijie Zhang, Ke Chen, Jiang Yang, Shu Zhang, Jianning Zhang, Yonghui Li, Hao Wang, Xiao‐Dong Zhang. Metabolic Enzyme‐Inspired Molecular Clusters for Advanced Type 2 Diabetic Complications by Alleviating Immunosuppression [J]. Advanced Materials, 2026, 38(10): e18331. https://doi.org/10.1002/adma.202518331 (智能筛选ɑ-淀粉酶抑制剂)

[2] Si Sun, Di Liu, Sufei Zhou, Yang Wang, Hao Wang, Ziliang Zheng, Xiao-Dong Zhang. Atomically Precise Clusterzymes: A Programmable Optoelectronic Platform for Neuroscience [J]. Advanced Science, 2026: e19438. https://doi.org/10.1002/advs.202519438

[3] Ruoli Zhao, Lingxia Li, Yuxing Yan, Xiaoyan Xue, Yuxuan Huo, Tianyu Liu, Hao Wang, Changlong Liu*, Shaofang Zhang*, Si Sun*, Xiao-Dong Zhang. Single-Atom Modulated Biocatalytic Selectivity on WSe2 Clusters [J]. ACS Applied Materials & Interfaces, 2025, 17(26): 38367-78. https://doi.org/10.1021/acsami.5c07454

[4] Si Sun, Di Liu, Nan Song, Qi Xin, Lingxia Li, Sufei Zhou, Huanhuan Qiao, Lijie Zhang, Yuxing Yan, Yili Wang, Ke Chen, Fangzhen Tian, Jiang Yang, Meili Guo, Hao Wang, Xiao-Dong Zhang. Single active Au1O5 clusters for metabolism-inspired sepsis management through immune regulation [J]. Nano Today, 2024, 58: 102416. https://doi.org/https://doi.org/10.1016/j.nantod.2024.102416

[5] Si Sun, Haile Liu, Qi Xin, Ke Chen, Huizhen Ma, S. Liu, Xiaoyu Mu, Wang Hao, S. Liu, Y. Gao, Y. Wang, J. Pei, R. Zhao, S. Zhang, X. Zhang, H. Wang, Y. Li, X. D. Zhang. Atomic Engineering of Clusterzyme for Relieving Acute Neuroinflammation through Lattice Expansion [J]. Nano Letters, 2021, 21(6): 2562-71. https://doi.org/10.1021/acs.nanolett.0c05148

[6] Shaofang Zhang#, Yonghui Li#, Si Sun#, Ling Liu, Xiaoyu Mu, Shuhu Liu, Menglu Jiao, Xinzhu Chen, Ke Chen, Huizhen Ma, Tuo Li, Xiaoyu Liu, Hao Wang, Jianning Zhang, Jiang Yang & Xiao-Dong Zhang*, Single-atom nanozymes catalytically surpassing naturally occurring enzymes as sustained stitching for brain trauma [J]. Nature Communications, 2022, 13(1): 4744. https://doi.org/10.1038/s41467-022-32411-z (超越天然酶亲和力的单原子纳米酶)

http://news.tju.edu.cn/info/1012/61947.htm

[7] Haile Liu#, Yonghui Li#, Si Sun#, Qi Xin, Shuhu Liu, Xiaoyu Mu, Xun Yuan, Ke Chen, Hao Wang, Kalman Varga, Wenbo Mi, Jiang Yang & Xiao-Dong Zhang*, Catalytically potent and selective clusterzymes for modulation of neuroinflammation through single-atom substitutions [J]. Nature Communications, 2021, 12(1): 114.https://doi.org/10.1038/s41467-020-20275-0 (提出团簇酶Clusterzyme的概念，揭示对神经炎症的调控, 入选Nature Communications的Editor Choice，入选ESI高被引)

[8] Di Liu#, Si Sun#, Huanhuan Qiao,# Qi Xin, Sufei Zhou, Lingxia Li, Nan Song, Lijie Zhang, Qi Chen, Fangzhen Tian, Xiaoyu Mu, Shaofang Zhang, Jing Zhang, Meili Guo, Hao Wang, Xiao-Dong Zhang, Ruiping Zhang. Ce12V6 Clusters with Multi-Enzymatic Activities for Sepsis Treatment [J]. Advanced Healthcare Materials, 2025, 14(8): 2401581. https://doi.org/10.1002/adhm.202401581

[9] Si Sun, Xinzhu Chen, Jing Chen, Junying Wang, Xiao-Dong Zhang. Nanozymes with bioorthogonal reaction for intelligence nanorobots [J]. Biophysics Reports, 2021, 7(1): 8-20. https://doi.org/10.52601/bpr.2021.200044

[10] Menglu Jiao#, Xiaoyu Mu#, Si Sun#, Haiyu Yang, Lufei Ouyang, Shaofang Zhang, Jiao Guo, Jian Meng, Ya Liu, Huizhen Ma, Hao Wang, Jiahui Pei, Ruoli Zhao, Tianyu Liu, Wei Long, Xiao-Dong Zhang, Ruiping Zhang. Establishing bilateral modulation of radiation induced redox damage via biocatalytic single atom engineering at Au clusters [J]. Chemical Engineering Journal, 2022, 445: 136793. https://doi.org/10.1016/j.cej.2022.136793

[11] Ruijuan Yan#, Si Sun#, Jiang Yang#, Wei Long, Junying Wang, Xiaoyu Mu, Qifeng Li, Wenting Hao, Shaofang Zhang, Haile Liu, Yalong Gao, Lufei Ouyang, Junchi Chen, Shuangjie Liu, Xiao-Dong Zhang, Dong Ming. Nanozyme-Based Bandage with Single-Atom Catalysis for Brain Trauma [J]. ACS Nano, 2019, 13(10): 11552-60. https://doi.org/10.1021/acsnano.9b05075 (单原子纳米酶绷带)

专利

1. 张晓东, 闫瑞娟, 孙思, 穆晓宇, 刘爽杰. 一种用于皮肤创伤的单原子纳米酶贴剂及制备方法[P]. 天津市：CN110960552B, 2022-04-05.

科研项目

1. 技术开发，基于金针复位技术的纳米酶涂层抗炎及促愈合作用研究，6万，2025.02-2026.12，主持

2. 国家重点研发计划，生物与信息融合（BT-IT融合）重大专项，新一代高相容生物植入电极的设计与应用，2363万，2021.12-2024.11，主要参与

3. 国家自然科学基金，面上项目，有机纳米酶分子的设计及其对外伤性脑损伤的治，55万，2020.1-2023.12，主要参与

4 国家自然科学基金，联合基金，电子辐射诱导增强CeO2团簇的电催化性能、催化机理及其在脑损伤中的应用，58万，2020.1-2022.12，主要参与

获奖情况

2025年国家资助博士后研究人员计划C档资助

2025年天津大学优秀博士学位论文

2024新医科与生物医药博士后海河学术交流活动二等奖