Brief Introduction:

Dr. Tian received her B.S. and Ph.D. degrees from Xiamen University. She then undertook postdoctoral research at Tsinghua University under the supervision of Prof. Sen-Fang Sui, a structural biologist, and was awarded the Outstanding Postdoctoral Fund of the Tsinghua–Peking University Center for Life Sciences. She is currently an Associate Researcher at Tianjin University.

Her research focuses on brain organoid development and the mechanisms of neurological disorders. By integrating brain organoids, neural signal encoding and decoding, brain–computer interface technologies, and in situ cryo-electron microscopy, she seeks to elucidate human neural development and to establish models of neurodevelopmental and neurodegenerative disorders, with the goal of identifying precise drug targets and developing novel strategies for disease prevention, prediction, diagnosis, and treatment.

As first author (including co-first author), she has published multiple papers in journals including Nature Structural & Molecular Biology and Nature Communications. She currently leads a project funded by the Youth Science Fund (Category C) of the National Natural Science Foundation of China.

Academic Achievements:

1. Xuyang Tian*, Jiayue Su*, Ziyi Wang, Tao Liu, Huifang Xiong, Shan Sun, Kunrong Mei#, Sen-Fang Sui#. Molecular Mechanism of PINK1 Regulation by The Hsp90 Machinery. https://doi.org/10.1038/s41467-025-65859-w. Nature Communications, 2025 (IF: 17.7).

2. Jiayue Su*, Xuyang Tian*, Hang Cheng*, Desheng Liu*, Ziyi Wang, Shan Sun, Hong-Wei Wang and Sen-Fang Sui. Structural insight into synergistic activation of human 3-methylcrotonyl-CoA carboxylase. doi:10.1038/s41594-024-01379-3. Nature Structural & Molecular Biology, 2024 (IF: 18.3).

3. Jiayue Su*, Xuyang Tian*, Ziyi Wang, Jawen Yang, Sen-Fang Sui. Structure basis of whole Tom20 location as the human TOM complex receptor. doi: 10.1093/pnasnexus/pgae269. PNAS Nexus. 2024 (IF: 4.8).

4. Li Y, Wu S, Tian X, Kong C, Hong W, Xiao T, Wang S, Wei Z, Su Z, Ren H, Song Y, Hu L, Lin D, Yao H, Han J, Chen X, Lin T. The structural basis of TRIM25-mediated regulation of RIG-I. doi:10.1016/j.jbc.2025.108367. J Biol Chem. 2025 (IF: 5.5).

5. Zhiming Su*, Xuyang Tian*, Huanjun Li, Zhiming Wei, Lifan Chen, Songqing Wang, Haixia Ren, Wenfeng Peng, Chongti Tang, Tianwei Lin, Shuaiqin Huang. Structural and functional insights into macrophage migration inhibitory factor from Oncomelania hupensis, the intermediate host of Schistosoma japonicum. doi: 10.1042/BCJ20200068. Biochem J 2020 (IF: 4.4).

Honors & Awards:

Outstanding Postdoctoral Fund of the Tsinghua–Peking University Center for Life Sciences.