Brief Introduction

Jianshu Hu, DPhil in Pharmacology from the University of Oxford, is currently an Associate Professor at Tianjin University School of Medicine. My long-term research focuses on cardiac ion channels and calcium-signaling electrophysiology, with extensive experience in cardiovascular electrophysiology, drug discovery, and brain–heart interaction mechanisms. My primary interests include the structure and functional regulation of ryanodine receptors (RyRs) and potassium channels, as well as their roles in catecholaminergic polymorphic ventricular tachycardia (CPVT), malignant hyperthermia, and related disorders. I have interdisciplinary expertise in electrophysiology, patch-clamp recording, cardiomyocyte isolation and imaging, genetically modified animal models, molecular simulation, and medicinal chemistry. I have published more than ten high-quality papers/articles in international academic journals and holds multiple granted patents.

Academic Achievements

1. Jianshu Hu, Elisa Venturi, Charalampos Sigalas, Takashi Murayama, Miyuki Nishi, Hiroshi Takeshima, Rebecca Sitsapesan. The biophysical properties of TRIC-A and TRIC-B and their interactions with RyR2 (invited article). The Journal of General Physiology, 2023, 155 (11): e202113070.

2. Gunasekaran Subramaniam, Katharina Schleicher, Duangnapa Kovanich, Anna Zerio, Milda Folkmanaite, Ying-Chi Chao, Nicoletta C. Surdo, Andreas Koschinski, Jianshu Hu, Arjen Scholten, Albert J.R. Heck, Maria Ercu, Anastasiia Sholokh, Kyung Chan Park, Enno Klussmann, Viviana Meraviglia, Milena Bellin, Sara Zanivan, Svenja Hester, Shabaz Mohammed, Manuela Zaccolo. Integrated Proteomics Unveils Nuclear PDE3A2 as a Regulator of Cardiac Myocyte Hypertrophy. Circulation Research. 2023,132(7):828-848.

3. Abigail D Wilson, Jianshu Hu, Charalampos Sigalas, Elisa Venturi, Héctor H Valdivia, Carmen R Valdivia, Ming Lei, Maria Musgaard, Rebecca Sitsapesan, The V2475F CPVT1 mutation yields distinct RyR2 channel populations that differ in their responses to cytosolic Ca2+ and Mg2+, The Journal of Physiology, 2021, 599(23): 5179-5201.

4. Yan Wang, Jian-Shu Hu (co-first author), Huang-Quan Lin, Tsz-Ming Ip, David Chi-Cheong Wan, Herbalog: A Tool for target-based identification of herbal drug efficacy through molecular docking, Phytomedicine, 2016, 23(12):1469-1474.

5. Yan Wang, Wai-Kit Law, Jian-Shu Hu (co-first author), Huang-Quan Lin, Tsz-Ming Ip, and David Chi-Cheong Wan, Discovery of FDA-Approved Drugs as Inhibitors of Fatty Acid Binding Protein 4 Using Molecular Docking Screening. Journal of Chemical Information and Modeling, 2014, 54 (11), 3046-3050.

Patents

Manuela Zaccolo; Ying-Chi Chao; Jianshu Hu; Patent application for a peptide for treating heart failure, 2025-05-09, UK, GB2507142.4

David Chi Cheong Wan; Yan Wang; Wai Kit Law; Jian Shu Hu; Tsz Ming Ip; Discovery of FDAapproved drugs as inhibitors of fatty acid binding protein 4 using molecular docking screening, 2016-05-15, 美国, US9968616B2