刘秀云-天津大学医学院

教授

刘秀云

职称：讲席教授

邮箱：xiuyun_liu@tju.edu.cn

个人简介

刘秀云，天津大学讲席教授，医学部副主任，药学院院长，先进医用材料与医疗器械全国重点实验室副主任，神经重症教育部医药基础研究创新中心执行主任，脑机交互与人机共融海河实验室副主任、国家重点研发项目首席科学家，天津市杰青，2022年入选国家级青年人才计划，2024年获国家重大人才工程项目。博士毕业于剑桥大学临床神经科学专业，后于加州大学旧金山分校及约翰霍普金斯大学麻醉重症系从事博士后研究，2021年入职天津大学。担任英国皇家医学会（Royal Society of Medicine）Fellow, 美国重症麻醉师协会学术委员会（SOCCA）委员、中国生物医学工程学会理事、传感器分会副主委，中国医学救援协会生命支持技术分会副会长、天津市围手术期医学研究会针灸与康复分会副会长。是《Journal of Intelligent Medicine》副主编，《Current Molecular Pharmacology》co-Editor, Military Medical Research编委。获《麻省理工科技评论》35岁以下科技创新35人（亚太区），全国首届新时代青年先锋奖、强国青年科学家引领计划、天津市科学技术进步奖一等奖（第一完成人）、天津市青年科技奖、天津市三八红旗手等荣誉。

主要研究方向

主要从事神经重症医学与重症脑机接口领域的研究工作，聚焦可逆性痴呆（脑积水）、痴呆、脑创伤、癫痫、中风、术后谵妄等脑疾病诊疗关键技术的开发，旨在解决当前神经重症的工程瓶颈问题，为医生提供精准治疗手段及策略。

代表性文章

1. Liu X#*, Donnelly J, Czosnyka M, Aries MJH, Brady K, Cardim D, Robba C, Cabeleira M, Kim DJ, Haubrich C, Hutchinson PJ, Smielewski P*. Cerebrovascular pressure reactivity monitoring using wavelet analysis in traumatic brain injury patients: A retrospective study. PLoS Med. 2017,14(7): e1002348. doi: 10.1371/journal.pmed.1002348.

2. Liu X#*, Donnelly J, Brady KM, Akiyoshi K, Bush B, Koehler RC, Lee JK, Hogue CW, Czosnyka M, Smielewski P, Brown CH*. Comparison of different metrics of cerebral autoregulation in association with major morbidity and mortality after cardiac surgery. Br J Anaesth. 2022,129(1):22-32. doi: 10.1016/j.bja.2022.03.029.

3. Yefeng Shen, Xin Li,* Jingnan Wu, Yuru Ma, Sven Borchmann, ZhenguoCheng, Yaohe Wang, Yongliang Zhao, Jian Song, Boyu Luo, Xiuyun Liu,* Yue Teng,* Zhiyuan Shi*. Bispecific Nanosystems Enable Multi-effector Immune Cell Retargeting for Hematologic Malignancy Therapy. Advanced Science. 2025

4. Liu X#*, Akiyoshi K, Nakano M, Brady K, Bush B, Nadkarni R, Venkataraman A, Koehler RC, Lee JK, Hogue CW, Czosnyka M, Smielewski P, Brown CH*. Determining Thresholds for Three Indices of Autoregulation to Identify the Lower Limit of Autoregulation During Cardiac Surgery. Crit Care Med. 2021,49(4):650-660. doi: 10.1097/CCM.0000000000004737.

5. Liu X#*, Nakano M, Yamaguchi A, Bush B, Akiyoshi K, Lee JK, Koehler RC, Hogue CW, Brown CH*. The association of bispectral index values and metrics of cerebral perfusion during cardiopulmonary bypass. J Clin Anesth. 2021,74:110395. doi: 10.1016/j.jclinane.2021.110395.

6. Liu X^#, Wang W^#, Liu M^#, Chen M^#, Pereira T, Doda D, Ke Y, Wang S, Wen D, Tong X, Li W, Yang Y, Han X, Sun Y, Song X, Hao C, Zhang Z, Liu X, Li C, Peng R, Song X, Yasi A, Pang M, Zhang K, He R, Wu L, Chen S, Chen W, Chao Y, Hu C, Zhang H, Zhou M, Wang K, Liu P, Chen C, Geng X, Qin Y, Gao D, Song E, Cheng L*, Chen X*, Ming D*. Recent applications of EEG-based brain-computer-interface in the medical field. Mil Med Res. 2025,12(1):14. doi: 10.1186/s40779-025-00598-z. (封面)

7. Liu, X#*., Li H#, Pang M, Liu J, Song X, He R, He M, J X, Ma Ch, Deng H, Wu Y, Ming D*. Photoacoustic imaging in brain disorders: Current progress and clinical applications. View 2024.0023（封面)

8. Liu X#*, Czosnyka M, Donnelly J, Cardim D, Cabeleira M, Hutchinson PJ, Hu X, Smielewski P*, Brady K*. Wavelet pressure reactivity index: a validation study. J Physiol. 2018,596(14):2797-2809. doi: 10.1113/JP274708.（封面)

9. Liu X^#, Song X^#, Czosnyka M, Robba C, Czosnyka Z , Summers J, Yu H, Gao G, Peter S, F Guo, Pang M* and Ming D*. Congenital hydrocephalus: a review of recent advances in genetic etiology and molecular mechanisms. Military Med Res.2024,11, 54. https://doi.org/10.1186/s40779-024-00560-5（封面)

10. Li Xiong#, Xiuyun Liu#, Ty Shang#, Peter Smielewski, Joseph Donnelly, Zhen-Ni Guo, Yi Yang, Thomas Leung, Marek Czosnyka, Rong Zhang*, Jia Liu*, Ka Sing Wong*. Impaired cerebral autoregulation: measurement and application to stroke. J Neurol Neurosurg Psychiatry. 2017,88(6):520-531.

11. Liu X#*, Mu J#, Han J#, Pang M, Zhang K, Zhai W, Su N, Ni G, Guo Z*, Ming D*. Heart-brain axis: low blood pressure during off-pump CABG surgery is associated with postoperative heart failure. Mil Med Res. 2024,11(1):18. doi: 10.1186/s40779-024-00522-x.

12. Liu X#*, Czosnyka M, Donnelly J, Budohoski KP, Varsos GV, Nasr N, Brady KM, Reinhard M, Hutchinson PJ, Smielewski P*. Comparison of frequency and time domain methods of assessment of cerebral autoregulation in traumatic brain injury. J Cereb Blood Flow Metab. 2015,35(2):248-56. doi: 10.1038/jcbfm.2014.192.

13. Liu X^#*, Vitt JR, Hetts SW, Gudelunas K, Ho N, Ko N, Hu X. Morphological changes of intracranial pressure quantifies vasodilatory effect of verapamil to treat cerebral vasospasm. J Neurointerv Surg.2020,12: 802-808 Doi 10.1136/neurintsurg-2019-015499

14. Sun Y#, Cheng L#, Si X, He R, Pereira T, Pang M, Zhang K, Song X, Ming D*, Liu X*. Multi-task transformer network for subject-independent iEEG seizure detection, Expert Systems with Applications, 2025,268:126282,

15. Sun Y, Guan M, Chen X, Feng F, He R, Huang L, Tong X, Zhou H*, Liu X*, Ming D*. Deep learning-based classification and segmentation of interictal epileptiform discharges using multichannel electroencephalography. Epilepsia. 2025. doi: 10.1111/epi.18463.

16. Ju Y#, Du M#, Wang Z#, Mu X#, Miao Y#, Guo Z, Wang D, Wang S, Ding J, Jin G, Zhang W, Qiao H, Su Y, Liu X*, Yuchi Z*, Tan X*, Wang Y*. Kukoamine A alleviates nephrolithiasis by inhibiting endogenous oxalate synthesis via the IL-6/JAK/STAT3/DAO signaling pathway. Phytomedicine. 2024, 11;135:156145. doi: 10.1016/j.phymed.2024.156145.

17. Liu X#, Song X#, Zhang K, Wang P, Wang Y, Han G, Du Y, Pang M* and Ming D*. Insights on neuropharmacological benefits and risks: Aconitum carmichaelii Debx. Biomed Pharmacother, 2024,181, 117669. https://doi.org/10.1016/j.biopha.2024.117669.

18. Anwar F#, Zhang K, Sun C, Pang M, Zhou W, Li H, He R, Liu X*, Ming D* . Hydrocephalus: An update on latest progress in pathophysiological and therapeutic research. Biomed Pharmacother. 2024, 23;181:117702. doi: 10.1016/j.biopha.2024.117702.

19. Wang Y*#, Li Y#, Zang X#, Moussian B, Shah D, Pang M, Zhu C, Qiao H, Tian X, Li J, Yang S, Zhang X, Du S, Sun S*, Yuchi Z*, Liu X*. Lead (Pb) load interacts with oxidative stress in Drosophila melanogaster through MTF-1/Nrf2/JNK mediated metallothionein expression. Ecotoxicology and Environmental Safety. 2025. 117921,292 .

20. Liu X #, Zhi H#, Czosnyka M, Robba C, Czosnyka Z, Summers L, Yu H, TongX, Gao G, Xiao G, Yu K, Xing Y, Mao R, Yin S, Chao Y, Li H, Pu K, Feng K, Pang M*, Ming D *. Advancing Hydrocephalus Management: Pathogenesis Insights, Therapeutic Innovations, and Emerging Challenges. Aging Dis. 2025. doi: 10.14336/AD.2024.1434.

21. Liu X#*, Maurits NM, Aries MJH, Czosnyka M, Ercole A, Donnelly J, Cardim D, Kim DJ, Dias C, Cabeleira M, Smielewski P. Monitoring of Optimal Cerebral Perfusion Pressure in Traumatic Brain Injured Patients Using a Multi-Window Weighting Algorithm. J Neurotrauma.2017, 34: 3081-3088 Doi 10.1089/neu.2017.5003

代表性专利

1. 美国专利 AN INPH PREDICTION METHOD AND DEVICE BASED ON THE NEW/OLD STIMULUS BCI PARADIGM (Pending)

2. 美国专利 APPLICATION OF CARBASALATE CALCIUM IN PREPARING DRUG FOR TREATMENT OF HYDROCEPHALUS (Pending)

3. 美国专利 MULTI-MODAL DATA ACQUISITION AND HYDROCEPHALUS DIAGNOSIS METHOD BASED ON CEREBROSPINAL FLUID CIRCULATION (Pending)

4. 美国专利 IN VIVO NON-INVASIVE INTRACRANIAL PRESSURE MONITORING DEVICE AND METHOD BASED ON MENINGEAL ABSORBANCE CHANGES (Pending)

5. 中国发明专利 CN117752317B 基于脑膜吸光度变化的在体无创颅内压监测装置及方法

6. 中国发明专利 CN117918856B 一种基于新旧刺激 BCI范式的iNPH 预测方法及设备

7. 中国发明专利CN117751892B 一种构造新生儿出血性脑积水模型的方法

8. 中国发明专利CN117936066B 一种基于视觉Oddball范式的iNPH 预测方法

9. 中国发明专利CN118177973B 基于增强现实的经颅多普勒颅内血管导航定位方法及系统

10. 中国发明专利 CN118380139B 一种基于U-Net网络单通道脑电癫痫棘波检测方法及装置

11. 中国发明专利 CN119185330B 卡巴匹林钙在制备治疗脑积水药物中的应用