个人简介

胡剑书，牛津大学药理学博士，现任天津大学医学院英才副教授。长期从事心脏离子通道及钙信号电生理研究，在心血管电生理、药物研发和脑心互作机制研究方面积累了丰富经验。重点研究关注兰尼碱受体（RyR）及钾离子通道的结构、功能调控，以及其与儿茶酚胺敏感性多形性室性心动过速、恶性高热等疾病的关系。具备电生理、膜片钳、心肌细胞分离与成像、基因修饰动物模型、分子模拟及药物化学等交叉研究能力。已在国际学术期刊发表十余篇高水平论文并获多项授权专利。

主要研究方向

神经疾病的脑心互作与神经心脏电生理机制及干预

代表性学术成果

1. Jianshu Hu, Elisa Venturi, Charalampos Sigalas, Takashi Murayama, Miyuki Nishi, Hiroshi Takeshima, Rebecca Sitsapesan. The biophysical properties of TRIC-A and TRIC-B and their interactions with RyR2. The Journal of General Physiology, 2023, 155 (11): e202113070.

2. Gunasekaran Subramaniam, Katharina Schleicher, Duangnapa Kovanich, Anna Zerio, Milda Folkmanaite, Ying-Chi Chao, Nicoletta C. Surdo, Andreas Koschinski, Jianshu Hu, Arjen Scholten, Albert J.R. Heck, Maria Ercu, Anastasiia Sholokh, Kyung Chan Park, Enno Klussmann, Viviana Meraviglia, Milena Bellin, Sara Zanivan, Svenja Hester, Shabaz Mohammed, Manuela Zaccolo. Integrated Proteomics Unveils Nuclear PDE3A2 as a Regulator of Cardiac Myocyte Hypertrophy. Circulation Research. 2023,132(7):828-848.

3. Abigail D Wilson, Jianshu Hu, Charalampos Sigalas, Elisa Venturi, Héctor H Valdivia, Carmen R Valdivia, Ming Lei, Maria Musgaard, Rebecca Sitsapesan, The V2475F CPVT1 mutation yields distinct RyR2 channel populations that differ in their responses to cytosolic Ca2+ and Mg2+, The Journal of Physiology, 2021, 599(23): 5179-5201.

4. Yan Wang, Jian-Shu Hu (co-first author), Huang-Quan Lin, Tsz-Ming Ip, David Chi-Cheong Wan, Herbalog: A Tool for target-based identification of herbal drug efficacy through molecular docking, Phytomedicine, 2016, 23(12):1469-1474.

5. Yan Wang, Wai-Kit Law, Jian-Shu Hu (co-first author), Huang-Quan Lin, Tsz-Ming Ip, and David Chi-Cheong Wan, Discovery of FDA-Approved Drugs as Inhibitors of Fatty Acid Binding Protein 4 Using Molecular Docking Screening. Journal of Chemical Information and Modeling, 2014, 54 (11), 3046-3050.

发明专利：

1. Manuela Zaccolo; Ying-Chi Chao; Jianshu Hu; Patent application for a peptide for treating heart failure, 2025-05-09, UK, GB2507142.4

2. David Chi Cheong Wan; Yan Wang; Wai Kit Law; Jian Shu Hu; Tsz Ming Ip; Discovery of FDAapproved drugs as inhibitors of fatty acid binding protein 4 using molecular docking screening, 2016-05-15, 美国, US9968616B2

3. 来鲁华; 刘莹; 孟虎; 胡剑书; 六氢吲唑类15-脂氧合酶激活剂及应用, 2015-11-25, 中国, ZL201510504578

科研项目

1. British Heart Foundation, Research Grant, FS/IBSRF/23/25155, Molecular, cardiac and neuronal mechanisms underlying catecholaminergic polymorphic ventricular tachycardia, 2023-08 至 2026-06

 2. British Heart Foundation, Chairs & Programme Grants, RG/17/6/32944, Topography, regulation and function of PDE-dependent cAMP nanodomains in cardiac myocytes, 2022-09 至 2023-05