W
王莉
职称：英才副教授
办公室：十教208A
邮箱：wangli9@tju.edu.cn
个人简介
天津大学英才副教授、硕士生导师，博士毕业于中国科学院大学，曾在苏州大学刘庄教授和程亮教授团队从事博士后研究。聚焦肿瘤、神经损伤等临床问题，创新开发生物活性纳米药物体系，研究其在生命系统中的作用机制，探索针对癌症、中枢神经损伤以及其他重大疾病的治疗新范式。近五年在Matter、ACS Nano、Materials Today等学术期刊发表论文40余篇，获授权中国发明专利2项。主持国家自然科学基金项目、博士后特别资助项目等4项，入选江苏省卓越博士后人才计划，担任Oncology and Translational Medicine青年编委及Nano Letter、Chemical Engineering Journal等多个国际期刊审稿人。
主要研究方向:
(1) 工程化细菌设计和构建，精准调控细菌的趋化导航和定植性能、增强免疫调节和癌细胞杀伤功能，建立智能精准肿瘤治疗新范式。
(2) 生物活性材料调控肿瘤-菌群-免疫互作网络机制研究，发展精准化免疫治疗新策略；
(3) 智能生物材料介导的中枢神经再生机制研究，发展调控神经网功能重塑的治疗新范式。
(4) 开发生物活性水滑石基纳米疫苗，强化铝佐剂协同效应，增强疫苗免疫应答及长效作用。
代表性学术成果:
(1) Cui Xiaoliang#, Wang Li#, Gao Xiang, Wu Jie, Hu Tian, Zhang Jun, Zhou Xiaozhong*, Zhang Ke-Qin*, and Cheng Liang*. Self-assembled Silk Fibroin Injectable Hydrogels Based on Layered Double Hydroxides for Spinal Cord Injury Repair. Matter, 2024, 7, 620. （IF:17.5）
(2) Cui Xiaoliang, Huang Cheng, Huang Yechen, Zhang Yuxuan, Wu Jie, Wang Gang, Zhang Jun, Wang Li*, Cheng Liang*, Zhang Ke-Qin*. Amplification of the metalloregulatory proteins in macrophages by bioactive ZnMn@SF hydrogels for spinal cord injury repair. ACS Nano, 2024, 18, 33614. （IF:16.0）
(3) Tang Wei, Wu Jie, Wang Li*, Wei Kailu, Pei Zifan, Gong Fei, Chen Linfu, Han Zhihui, Yang Yuqi, Dai Yizhi, Cui Xiaoliang, Cheng Liang*. Bioactive Layered Double Hydroxides for Synergistic Sonodynamic/Cuproptosis Anticancer Therapy with Elicitation of the Immune Response, ACS Nano, 2024, 18, 10495. (ESI高被引，IF:16.0)
(4) Wu Jie, Wang Li*, Tang Wei, Cui Xiaoliang, Wei Kailu, Cheng Shuning, Pei Zifan, Lei Huali, Liu Zhuang, Cheng Liang*, Amplifying Oxidation Stress and T-cell Activation by Bioactive Layered Double Hydroxide Sonosensitizers for Enhanced Cancer Immunotherapy, Materials Today, 2023, 68, 164. （IF:22）
(5) Wang Li, Zhang Baorui, Yang Xueting, Guo Shuaitian, Waterhouse Geoffrey I. N., Song Guangrong, Guan Shanyue*, Liu Aihua*, Cheng Liang*, Zhou Shuyun, Targeted Alleviation of Ischemic Stroke Reperfusion via Atorvastatin-Ferritin Gd-Layered Double Hydroxide. Bioact. Mater., 2023, 20, 126. (ESI高被引, IF:20.3)
(6) Cui Xiaoliang, Wang Xianwen, Liu Siying, Wang Lilei, Li Menghong, Zhang Jun*, Wang Li*, Zhang Ke-Qin*. Silk fibroin‐based biomaterials for spinal cord injury repair: Recent advances and future prospects. BMEMat, (In press, IF:15.5)
(7) Wang Li, Mao Zhuo, Wu Jie, Cui Xiaoliang, Wang Yuanjie, Yang Nailin, Ge Jun, Lei Huali, Han Zhihui, Tang Wei, Guan Shanyue, Cheng Liang*, Engineering Layered Double Hydroxide-based Sonocatalysts for Enhanced Sonodynamic Immunotherapy. Nano Today, 2023, 49, 101782. （IF:10.9）
(8) Wang Li, Zhuang Liang, He Shan*, Tian Fangzhen, Yang Xueting, Guan Shanyue*, Waterhouse Geoffrey I. N., Zhou Shuyun, Nanocarbon Framework-Supported Ultrafine Mo2C@MoOx Nanoclusters for Photothermal-Enhanced TumorSpecific Tandem Catalysis Therapy. ACS Appl. Mater. Interfaces, 2021, 13, 59649. （IF:8.2）
(9) Wang Li, Xu Siming, Yang Xueting, He Shan, Guan Shanyue*, Waterhouse Geoffrey I. N., Zhou Shuyun, Exploiting Co Defects in CoFe-Layered Double Hydroxide (CoFe-LDH) Derivatives for Highly Efficient Photothermal Cancer Therapy. ACS Appl. Mater. Interfaces, 2020, 12, 54916. （IF:8.2）
(10) Wang Li, Qu Xiaozhong, Zhao Yunxuan, Weng Yangziwan, Waterhouse Geoffrey I. N., Yan Hong, Guan Shanyue*, Zhou Shuyun, Exploiting Single Atom Iron Centers in a Porphyrin-like MOF for Efficient Cancer Phototherapy. ACS Appl. Mater. Interfaces, 2019, 11, 35228. （IF:8.2）
(11) Wang Li, Guan Shanyue*, Weng Yangziwan, Xu Siming, Lu Heng, Meng Xiangmin, Zhou Shuyun, Highly Efficient Vacancy-Driven Photothermal Therapy Mediated by Ultrathin MnO2 Nanosheets. ACS Appl. Mater. Interfaces, 2019, 11, 6267. （IF:8.2）
(12) Guan Shanyue#, Wang Li#, Xu Siming, Yang Di, Waterhouse Geoffrey I. N., Qu Xiaozhong, Zhou Shuyun, Vacancy Enhanced Generation of Singlet Oxygen for Photodynamic Therapy. Chem. Sci., 2019, 10, 2336. （IF:7.4）
科研项目
1. 国家自然科学基金委员会，青年项目，2024-01至2026-12，30万，在研，主持
2. 中国博士后科学基金委，特别资助项目（站中），2023-07至2025-03，18万，结题，主持
3. 中国博士后科学基金委，面上项目，2023-01至2025-03，8万，结题，主持
4. 江苏省人力资源和社会保障厅，卓越博士后计划人才项目，2022-2024，30万，结题，主持
5. 中科院青年创新促进会，人才项目，2019-01至2022-12，80万，结题，参与
6. 国家自然科学基金委员会，青年项目，2019-01至2021-12，27.5万，结题，参与
7. 中国科学院理化技术研究所，所长基金，2020-01至2021-12，10万，结题，参与
