个人简介

孙思，博士，天津大学助理研究员。毕业于天津大学理学院，师从张晓东教授。长期聚焦于团簇分子的理性设计及其在重大疾病中的应用。近年来，在Nature Communications，Advanced Materials，ACS Nano，Nano Letters, Nano Today等TOP期刊发表论文30余篇，授权国家发明专利1项。参与国家重点研发计划、国自然面上、天津市面上项目等。入选2025年国家资助博士后研究人员计划C档资助，获天津大学2025年度天津大学优秀博士学位论文。

代表性学术成果

[1] Haile Liu#, Yonghui Li#, Si Sun#, Qi Xin, Shuhu Liu, Xiaoyu Mu, Xun Yuan, Ke Chen, Hao Wang, Kalman Varga, Wenbo Mi, Jiang Yang & Xiao-Dong Zhang*, Catalytically potent and selective clusterzymes for modulation of neuroinflammation through single-atom substitutions [J]. Nature Communications, 2021, 12(1): 114.https://doi.org/10.1038/s41467-020-20275-0 (提出团簇酶Clusterzyme的概念，揭示对神经炎症的调控, 入选Nature Communications的Editor Choice，入选ESI高被引)

[2] Qi Xin#, Fangzhen Tian#, Huanhuan Qiao#, Guo Li, Yili Wang, Lingxia Li, Lijie Zhang, Nan Song, Ke Chen, Yuxing Yan, Shasha Li, Huizhen Ma, Haile Liu, Hao Wang, Jiang Yang, Si Sun*, Yonghui Li*, Xiao-Dong Zhang*, Machine Learning Assisted Engineering of Atomically Precise Cluster-Derived Artificial Hydrolases for Lipid Metabolism Diseases [J]. Materials Today, 2026, 95: 103294.https://doi.org/10.1016/j.mattod.2026.103294 (机器学习筛选具有甘油三酯脂肪酶活性的原子精度团簇)

[3] Si Sun#, Fangzhen Tian#, Huanhuan Qiao#, Qi Xin, Xinxu Zhang, Nan Song, Yuxing Yan, Ling Liu, Yili Wang, Lijie Zhang, Ke Chen, Jiang Yang, Shu Zhang, Jianning Zhang, Yonghui Li*, Hao Wang*, Xiao‐Dong Zhang*. Metabolic Enzyme‐Inspired Molecular Clusters for Advanced Type 2 Diabetic Complications by Alleviating Immunosuppression [J]. Advanced Materials, 2026, 38(10): e18331.https://doi.org/10.1002/adma.202518331 (智能筛选ɑ-淀粉酶抑制剂)

[4] Si Sun#, Di Liu#, Sufei Zhou#, Yang Wang#, Hao Wang, Ziliang Zheng*, Xiao-Dong Zhang*. Atomically Precise Clusterzymes: A Programmable Optoelectronic Platform for Neuroscience [J]. Advanced Science, 2026, 13(16): e19438. https://doi.org/10.1002/advs.202519438

[5] Ruoli Zhao, Lingxia Li, Yuxing Yan, Xiaoyan Xue, Yuxuan Huo, Tianyu Liu, Hao Wang, Changlong Liu*. Shaofang Zhang*, Si Sun*, Xiao-Dong Zhang. Single-Atom Modulated Biocatalytic Selectivity on WSe₂ Clusters [J]. ACS Applied Materials & Interfaces, 2025, 17(26): 38367-78. https://doi.org/10.1021/acsami.5c07454

[6] Si Sun#, Di Liu#, Nan Song, Qi Xin, Lingxia Li, Sufei Zhou, Huanhuan Qiao, Lijie Zhang, Yuxing Yan, Yili Wang, Ke Chen, Fangzhen Tian, Jiang Yang, Meili Guo*, Hao Wang*, Xiao-Dong Zhang*. Single active Au₁O₅ clusters for metabolism-inspired sepsis management through immune regulation [J]. Nano Today, 2024, 58: 102416. https://doi.org/https://doi.org/10.1016/j.nantod.2024.102416

[7] Si Sun#, Haile Liu#, Qi Xin#, Ke Chen, Huizhen Ma, S. Liu, Xiaoyu Mu, Wang Hao, S. Liu, Y. Gao, Y. Wang, J. Pei, R. Zhao, S. Zhang, X. Zhang, H. Wang, Y. Li*, X. D. Zhang*. Atomic Engineering of Clusterzyme for Relieving Acute Neuroinflammation through Lattice Expansion [J]. Nano Letters, 2021, 21(6): 2562-71. https://doi.org/10.1021/acs.nanolett.0c05148

[8] Shaofang Zhang#, Yonghui Li#, Si Sun#, Ling Liu, Xiaoyu Mu, Shuhu Liu, Menglu Jiao, Xinzhu Chen, Ke Chen, Huizhen Ma, Tuo Li, Xiaoyu Liu, Hao Wang, Jianning Zhang, Jiang Yang & Xiao-Dong Zhang*, Single-atom nanozymes catalytically surpassing naturally occurring enzymes as sustained stitching for brain trauma [J]. Nature Communications, 2022, 13(1): 4744. https://doi.org/10.1038/s41467-022-32411-z (超越天然酶亲和力的单原子纳米酶)

http://news.tju.edu.cn/info/1012/61947.htm

[9] Di Liu#, Si Sun#, Huanhuan Qiao,# Qi Xin, Sufei Zhou, Lingxia Li, Nan Song, Lijie Zhang, Qi Chen, Fangzhen Tian, Xiaoyu Mu, Shaofang Zhang, Jing Zhang, Meili Guo, Hao Wang*, Xiao-Dong Zhang*, Ruiping Zhang*. Ce₁₂V₆ Clusters with Multi-Enzymatic Activities for Sepsis Treatment [J]. Advanced Healthcare Materials, 2025, 14(8): 2401581.https://doi.org/10.1002/adhm.202401581

[10] Si Sun#, Xinzhu Chen#, Jing Chen, Junying Wang, Xiao-Dong Zhang*. Nanozymes with bioorthogonal reaction for intelligence nanorobots [J]. Biophysics Reports, 2021, 7(1): 8-20. https://doi.org/10.52601/bpr.2021.200044

[11] Menglu Jiao#, Xiaoyu Mu#, Si Sun#, Haiyu Yang, Lufei Ouyang, Shaofang Zhang, Jiao Guo, Jian Meng, Ya Liu, Huizhen Ma, Hao Wang, Jiahui Pei, Ruoli Zhao, Tianyu Liu, Wei Long, Xiao-Dong Zhang, Ruiping Zhang. Establishing bilateral modulation of radiation induced redox damage via biocatalytic single atom engineering at Au clusters [J]. Chemical Engineering Journal, 2022, 445: 136793. https://doi.org/10.1016/j.cej.2022.136793

[12] Ruijuan Yan#, Si Sun#, Jiang Yang#, Wei Long, Junying Wang, Xiaoyu Mu, Qifeng Li, Wenting Hao, Shaofang Zhang, Haile Liu, Yalong Gao, Lufei Ouyang, Junchi Chen, Shuangjie Liu, Xiao-Dong Zhang, Dong Ming. Nanozyme-Based Bandage with Single-Atom Catalysis for Brain Trauma [J]. ACS Nano, 2019, 13(10): 11552-60. https://doi.org/10.1021/acsnano.9b05075(单原子纳米酶绷带)

专利

1. 张晓东, 闫瑞娟, 孙思, 穆晓宇, 刘爽杰. 一种用于皮肤创伤的单原子纳米酶贴剂及制备方法[P]. 天津市：CN110960552B, 2022-04-05.

科研项目

1. 技术开发，基于金针复位技术的纳米酶涂层抗炎及促愈合作用研究，6万，2025.02-2026.12，主持

2. 国家重点研发计划，生物与信息融合（BT-IT融合）重大专项，新一代高相容生物植入电极的设计与应用，2363万，2021.12-2024.11，主要参与

3. 国家自然科学基金，面上项目，有机纳米酶分子的设计及其对外伤性脑损伤的治，55万，2020.1-2023.12，主要参与

4 国家自然科学基金，联合基金，电子辐射诱导增强CeO₂团簇的电催化性能、催化机理及其在脑损伤中的应用，58万，2020.1-2022.12，主要参与

获奖情况

2025年国家资助博士后研究人员计划C档资助

2025年天津大学优秀博士学位论文

2024新医科与生物医药博士后海河学术交流活动二等奖